UNIVERSALLY VALID REDUCTION OF MULTISCALE STOCHASTIC BIOCHEMICAL SYSTEMS USING SIMPLE NON-ELEMENTARY PROPENSITIES.

Universally valid reduction of multiscale stochastic biochemical systems using simple non-elementary propensities.

Biochemical systems consist of numerous elementary reactions governed by the law of mass action.However, experimentally characterizing all the elementary reactions is nearly impossible.Thus, over a century, their deterministic models that typically contain rapid reversible bindings have been simplified with non-elementary reaction functions (e.g.,

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Long-term consistent use of a vaginal microbicide gel among HIV-1 sero-discordant couples in a phase III clinical trial (MDP 301) in rural south-west Uganda

Abstract Background A safe and effective vaginal microbicide could substantially reduce HIV acquisition for women.Consistent gel use is, however, of great importance to ensure continued protection against HIV infection, even with a safe and effective microbicide.We assessed the long-term correlates of consistent gel use in the MDP 301 clinical tria

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